Limited interventional human studies suggest that probiotic supplementation may be a beneficial strategy for promoting weight loss when added to a nutritional intervention via their effects on lipid absorption and metabolic signaling molecules. The purpose of this study is to evaluate the effects of addition of a probiotic supplementation to a weight loss intervention on body weight, body composition and overall health in overweight adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
152
PEPS - Université Laval
Québec, Quebec, Canada
Change from Baseline body weight at 12 weeks
Time frame: 12 weeks
Change from Baseline BMI at 12 weeks
Time frame: 12 weeks
Change from Baseline waist circumference data at 12 weeks
Time frame: 12 weeks
Change from Baseline sagittal abdominal diameter data at 12 weeks
Time frame: 12 weeks
Change from Baseline body composition at 12 weeks
DXA
Time frame: 12 weeks
Change from Baseline stress level at 12 weeks
Questionnaire
Time frame: 12 weeks
Change from Baseline anxiety level at 12 weeks
Questionnaire
Time frame: 12 weeks
Change from Baseline depression symptoms at 12 weeks
Questionnaire
Time frame: 12 weeks
Change from Baseline sleeping habits at 12 weeks
Questionnaire
Time frame: 12 weeks
Change from Baseline intestinal microbiota composition at 12 weeks
Changes in the concentrations of the probiotic strains in the stools will be measured with strain specific DNA in fecal samples.
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Time frame: 12 weeks
Change from Baseline C-reactive protein at 12 weeks
Time frame: 12 weeks
Change from Baseline TNF-a at 12 weeks
Time frame: 12 weeks
Change from Baseline interleukin-6 at 12 weeks
Time frame: 12 weeks
Change from Baseline lipopolysaccharide (LPS) at 12 weeks
Time frame: 12 weeks