microRNA Profiles Identification in Adeno Carcinoma Prostate Cancer

Assuta Medical Center120 enrolled

Overview

In our study, the investigators want to find correlation between circulating miRNAs associated with prostate cancer metastases to bones and to lymph nodes separately with results of 68Ga-PSMA ligand PET (positron emission computed) imaging.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Prostate Carcinosarcoma

Interventions

High PSA levelsBIOLOGICAL

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Proven Adeno-carcinoma * Underwent prostatectomy and still present high PSA levels * Refered to PSMA exam. Exclusion Criteria: * Below 18 years old * HIV/HBV (hepatitis B virus)/HCV (hepatitis C virus) positive * Additional malignancy during the past five years.

Outcomes

Primary Outcomes

Metastasis size and location

Location of metastasis by a report analyzing the pathological examination (PET-MR output).

Time frame: 18 months

Secondary Outcomes

MicroRNA profile by using Nano-string technology validated by real time PCR

Validation of MicroRNA pattern by using real time PCR

Time frame: 24 months

Central Contacts

Natalia Goldberg, MD

CONTACT

972547833789 natalia.goldberg@gmail.com

Data from ClinicalTrials.gov

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