Atrial fibrillation in the elderly is a complex condition due to the high number of frequently associated comorbidities such kidney disease. Direct oral anticoagulants (dabigatran, rivaroxaban and apixaban) are indicated for preventing thromboembolic events but renal function should be closely monitored for this age group when these drugs are used. Dosing recommendations for prevention of stroke are based on renal clearance of creatinine (ClCr) estimated using the Cockcroft-Gault formula. It is well known that ClCr estimates predict a steeper decline with advancing age than Glomerular Filtration Rate (GFR) estimates. This raises the possibility that substitution of commonly reported GFR for estimated CrCl could result in different plasmatic concentrations of oral direct anticoagulants. The aim of this study was to compare estimates of ClCr and GFR and determine the impact on the plasmatic concentration of these drugs in elderly patients with non-valvular atrial fibrillation.
Study Type
OBSERVATIONAL
Enrollment
116
2 additional tubes of blood samples are collected during a blood sample realized for the patient's care
University Hospital
Montpellier, France
renal function estimated by different glomerular filtration rate equations and by clearance of creatinine formula
Time frame: At the inclusion
plasmatic activity of direct oral anticoagulant at steady state residual time (anti-Xa or anti-IIa)
Time frame: At the inclusion
plasmatic concentration of direct oral anticoagulant at steady state residual time
Time frame: At the inclusion
Number of haemorrhagic or thrombotic adverse events (serious or not) affecting patients
Reported by a trained physician after a phone interview with the patient coupled with medication adherence assessment using 6-item Moriksy scale. An internal questionnaire will be used to collect data.
Time frame: At 1 month
Number of haemorrhagic or thrombotic adverse events (serious or not) and unexpected events affecting patients
Reported by a trained physician after a phone interview with the general practitioner and the patient coupled with medication adherence assessment using 6-item Moriksy scale. An internal questionnaire will be used to collect data.
Time frame: At 6 months
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