Investigators will aim to conduct an observational study in order to assess very thoroughly all patients implanted by Extracorporeal carbon dioxide removal (ECCO2R) in 10 critical care units of Paris and its surburb (APHP, Assistance Publique des hôpitaux de Paris). Secondary objectives will be: 1. to assess efficacy and safety of ECCO2R, 2. to compare the data issue from the registry to others studies assessing the same population and to other centers and 3. to compare the different ECCOR devices in terms of efficacy and adverse events.
The registry will be conducted prospectively during 2 years in 10 ICUs of l'APHP on behalf on the CEDIT. The 10 centers are : (1) ICU of l'hôpital europeén Georges Pompidou, (2) ICU of l'Hôpital Louis Mourier, (3) ICU of l'Hôpital de Bicêtre, (4) ICU of GHPS, (5) Respiratory ICU of GHPS, (6) ICU of l'Hôpital Lariboisière (7) ICU of l'Hôpital Cochin (8) ICU of l'Hôpital Saint-Antoine (9)ICU of l'Hôpital Henri Mondor and (10) ICU of l'Hôpital Tenon. The primary outcome will be the number of patients implanted by ECCO2R monthly in each center during the 2 years period study. Secondary outcomes will be ICU-mortality, invasive ventilation duration, non invasive ventilation duration, ICU duration, modalities of ventilation at the ICU discharge, hemorragic complications due to the ECCOR device, thrombotic complications due to ECCO2R device, intravascular hemolysis due to ECCO2R device, duration of ECCO2R, adjunct therapy to ECCO2R and reasons of ECCO2R discontinuation.
Study Type
OBSERVATIONAL
Enrollment
200
The ECCO2R system was developed from the principle of ECMO systems by underscoring the importance of carbon dioxide elimination rather than direct improvement of oxygenation in some patients. The circuit of the ECCO2R system can be set up in venovenous (VV) or arteriovenous (AV). For VV setup, a low flow pump is used to maintain a low extracorporeal flow rate using only 20-30 % of cardiac output. The ECCO2R system does not provide complete pulmonary function as it can achieve only limited oxygenation but provides predominantly carbon dioxide removal. As neither VV nor AV circuit allows full cardiopulmonary bypass, the system provides respiratory function but no cardiac support
Assistance Publique - Hopitaux de Paris
Paris, France
RECRUITINGIncidence of ECCO2R use
Number of ECCO2R implantation monthly by center
Time frame: Recorded monthly up to 100 weeks (24 months)
ICU mortality
Time frame: Recorded From date of ICU admission until the date of death or ICU discharge, assessed up to 100 weeks
Duration of mechanical ventilation
Time frame: Recorded from ICU admission until the date of death or ICU discharge,assessed up to 100 weeks
ICU duration
Time frame: Recorded from ICU admission until the date of death or ICU discharge,assessed up to 100 weeks
Ventilation modalities at discharge
Time frame: Recorded from the initiation of ventilation until ventilation removal,assessed up to 100 weeks
hemorragic and thrombotic complications
Time frame: Recorded from the date of ECCO2R implantation until the removal of the device,assessed up to 100 weeks
hemolysis
Time frame: Recorded from the date of ECCO2R implantation until the removal of the device,assessed up to 100 weeks
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