Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure

First Affiliated Hospital of Zhejiang University350 enrolled

Overview

Acute-on-chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Systemic inflammation and susceptibility to infection are characteristic pathophysiological features. Prostaglandin E2 (PGE2) could subdue systemic inflammation and alleviate liver injury in mice model. However, there are no studies evaluating PGE2 as a predictor of early mortality.This study is designed to investigate whether plasma PGE2 and its receptors are associated with development of MOF and predict short-term mortality in patients with acute-on-chronic liver failure. By the way, we will also measure several other potential predictive factors (C-reactive protein,severe hyponatremia, Second infections,Diabetes mellitus,High density lipoprotein,interleukin-10,serum bile acids,ferritin,the neutrophil to lymphocyte ratio,soluable urokinase plasminogen activator receptor,vWF-Ag levels and FVIII-to-PC ratios).

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Acute-On-Chronic Liver Failure Cirrhosis and Chronic Liver Disease

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of acute-on-chronic liver failure according to Asian-Pacific Association for the Study of the Liver (APASL) diagnostic criteria Exclusion Criteria: * Hepatocellular carcinoma(HCC) * Portal vein thrombosis * Pregnancy * Human immunodeficiency virus (HIV) * Patients who had received immunomodulator,or cytotoxic/immunosuppressive therapy within at least the preceding 12 months

Outcomes

Primary Outcomes

all cause mortality

Time frame: 90 days

incidence of multiorgan failure

Time frame: 90 days

all cause mortality

Time frame: 30 days