A Trial to Assess the Pain-control Efficacy of Intra-articular Toradol Compared to Oral NSAIDs

The University of Texas Health Science Center, Houston

Overview

The study objective is to determine whether a single intra-articular dose of an anti-inflammatory (Toradol) will reduce the need for other analgesic medications and, if so, how long the benefits will last.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Arthritic Knee Pain

Interventions

ToradolDRUG

3-ml solution that contains 2 ml of normal saline and 1 ml of Toradol, 30 mg, will be infused into the affected joint.

Oral NSAIDDRUG

800mg Motrin will be administered. (non-steroidal anti-inflammatory drug (NSAID))

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with radiographic evidence of osteoarthritis (OA) who present to the ED with a chief complaint of knee pain that the treating provider attributes to their arthritis. Exclusion Criteria: * Acute knee trauma * Intra-articular steroid injection within 6 months * History of gout or rheumatoid arthritis * X ray evidence of pathologic fracture, malignancy, or other non-OA cause of symptoms * Signs or symptoms or high risk of acute infection: Recent fevers and chills; Erythema, warmth, or pain out of proportion to exam; History of hemodialysis; History of IV drug use * Lidocaine allergy * Any contraindication to NSAID therapy, including: Allergy; Pregnancy; History of renal insufficiency; History of gastritis, GERD or GI bleeding; Primary care physician's restriction of its use * Contraindication to the procedure, including: Hemophilia; History of total knee replacement of the affected joint * An inability to give informed consent; Active psychosis; Diminished capacity requiring another person to provide consent for medical treatment * An inability to be contacted for follow-up