N2 Lung Cancer Project: Neoadjuvant Treatment Followed Surgery Versus Chemoradiation

Grupo de Investigación Clínica en Oncología Radioterapia294 enrolled

Overview

The objective of this multicenter retrospective study is to compare overall survival in patients with stage IIIA-N2 NSCLC treated with neoadjuvant treatment and surgery versus definitive chemoradiation. Secondary objectives are to analyze disease-free survival, median survival, locoregional and distant relapses as well as mortality and toxicity related to treatment.

Based on data published by the Intergroup 0139 trial, induction therapy followed by surgery in patients with stage IIIA-N2 NSCLC can increase overall survival compared to exclusive radical chemoradiation treatment. The major handicap of all studies addressing the role of surgery in IIIA-N2 NSCLC is the difficulty of recruiting patients. Therefore, multicenter studies are necessary to confirm the hypothesis generated by the INT 0139.

Study Type

OBSERVATIONAL

Enrollment

294

Conditions

Non-small-Cell Lung Carcinoma Surgery Stage IIIA-N2 Chemoradiation Survival

Interventions

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Stage IIIA (N2) disease * Potentially resectable disease * Stage Lung Cancer with CT scan or PET-CT. * N2 involvement: it is not necessary pathological proof. * No progression after induction treatment. Exclusion Criteria: * T4 or N3 stage. * Bulky disease or not resectable.

Outcomes

Primary Outcomes

Overall survival

Time frame: 5 years

Secondary Outcomes

Disease-free survival

Time frame: 5 years

Patterns of Relapse

Time frame: 5 years

Mortality

Time frame: 5 years

N2 Lung Cancer Project: Neoadjuvant Treatment Followed Surgery Versus Chemoradiation

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes