Study was designed to evaluate efficacy of mucolytic solution ingested before upper endoscopy on visibility of gastric mucosa.
Residual gastric content containing mucus, bubbles, bile and food particles may limit visibility of gastric mucosa and therefore diagnostic yield of upper endoscopy, especially in cases of early neoplastic lesions. Data on benefit of peroral mucolytic solution administered before upper endoscopy are limited.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
QUADRUPLE
Enrollment
150
Digestive Diseases Center
Ostrava, Czechia
RECRUITING"Visibility score" evaluated by blinded performing endoscopist
"Visibility score" (0-25 points) counted as the sum of visibility score in the esophagus (0-5), fundus (0-5), corpus (0-5) and atrum (0-5) of the stomach and in the duodenum (0-5).
Time frame: through study completion, an average of 3 months
"Visibility score" evaluated by three blinded endoscopists using 11 endoscopic images captured during endoscopy.
"Visibility score" (0-25 points) counted as the sum of visibility score in the esophagus (0-5), fundus (0-5), corpus (0-5) and atrum (0-5) of the stomach and in the duodenum (0-5).
Time frame: through study completion, an average of 3 months
Residual fluid in the stomach evaluated by blinded performing endoscopist
0-3 point scale
Time frame: through study completion, an average of 3 months
Duration of endoscopy
time between introduction and withdrawal of the endoscopy
Time frame: through study completion, an average of 3 months
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