This study evaluate the effects of acupuncture method on the recurrence of ischemic stroke patients.Half of participants will receive "Huo Xue San Feng" acupuncture combining 1 antihypertensive medication on the routine ischemic stroke treatments' basis. While the other half will receive 1 antihypertensive medication and basic treatments for ischemic stroke.
Under recuiting 480 patients come from 5 hospitals in China.Eligible patients will be randomly assigned into 2 groups: treatment group and control group. The treatment group will receive "Huo Xue San Feng" acupuncture combining 1 antihypertensive medication on the routine ischemic stroke treatments' basis. The control group will receive 1 antihypertensive medication and basic treatments for ischemic stroke. "Huo Xue San Feng" acupuncture will be given six sessions weekly for the first 6 weeks and three times weekly for the next 6 weeks. A 9-month follow-up will thereafter be conducted. Antihypertensive medications will be adjusted based on BP levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
480
1. "Huo Xue San Feng" acupuncture method: Patients will recieve the acupuncture treatment,choose the bilateral point:Renying(ST9),Hegu(L14),Taichong(LR3),Quchi(LI11),Zusanli(ST36). 2. Routine care for ischemic stroke :patients will recieve the acupuncture treatment,choose the point:Neiguan(PC6),Renzhong(10),Sanyinjiao(SP6),Jiquan(HT1),Chize(LU5),Weizhong(BL40). 3. Drugs: Antihypertensive drugs.Patients will be treated 1 of 5 type of antihypertensive drugs,include ARB、ACEI、βreceptor blocker,CCB,Diuretic. The time of therapy will consist of 6 times per week in Continuous treatment phase(1st-6th week after enrollment) and 3 times per week(once every other day) in Consolidation treatment phase(7th-tewlve week after enrollment)
Chongqing Traditional Chinese Medicine Hospital
Chongqing, China
NOT_YET_RECRUITINGMIANYANG Hospital of Traditional Chinese Medicine
Mianyang, China
NOT_YET_RECRUITINGLONGHUA Hospital Shanghai University of Traditional Chinese Medicine
Shanghai, China
The Effects of Acupuncture on Reccurence of Ischemic Stroke
The effects of acupuncture on reccurence of ischemic stroke assessed by China's Guidelines of Diagnosis and Treatment of Acute Ischemic Stroke 2014 and China's Guidelines of Diagnosis and Treatment of Cerebral Hemorrhage 2014.
Time frame: 1 year after enrollment
24-hour ambulatory blood pressure
Time frame: the first day、6 weeks、12 weeks after enrollment
Daily Blood Pressure by Electronic Sphygmomanometer
Time frame: 1 year after enrollment
Antihypertensive Drug Stop/Resumption/Increasing Rate
Time frame: 1 year after enrollment
Nitric Oxide(NO)
Time frame: the first day、12 weeks,6 months after enrollment
Endothelin(ET)
Time frame: the first day、12 weeks,6 months after enrollment
The Cardiac Color Doppler Ultrasonography
Time frame: the first day、12 weeks after enrollment
Carotid Color Ultrasonography
Time frame: the first day、12 weeks after enrollment
Brain Color Doppler Ultrasonography
Time frame: the first day、12 weeks after enrollment
Lower Extremity Color Ultrasonography
Time frame: the first day、12 weeks after enrollment
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Shenzhen Bao'an Traditional Chinese Medicine Hospital Group
Shenzhen, China
NOT_YET_RECRUITINGFirst Teaching Hospital of Tianjin University of TCM
Tianjin, China
RECRUITINGTCM syndrome score
Time frame: the first day、6 weeks、12 weeks after enrollment
Short Form 36-item Health Survey (SF-36)
Time frame: the first day、6 weeks、12 weeks after enrollment
National Institute of Health stroke scale (NIHSS),as well as Barthel Index (BI) scale
Time frame: the first day、12 weeks after enrollment
Essen stroke risk score (ESRS)
Time frame: the first day、1 year after enrollment
All-caused Morality
Time frame: 1 year after enrollment
Serum homocysteine(Hcy)
Time frame: the first day、12 weeks,6 months after enrollment
Soluble CD40L(sCD40L)
Time frame: the first day、12 weeks,6 months after enrollment
Copeptin
Time frame: the first day、12 weeks,6 months after enrollment