Evaluation of PET/MRI Using a Somatostatin Analog Tracer as a Novel Approach to Detecting Pathology in High Risk TB-exposed Contacts

Inclusion Criteria: 1. Age 21 years or over 2. Close household contact of any patient with newly-diagnosed (within last 2 months) smear positive pulmonary TB (close contact defined as sleeping in the same house for at least one month with a TB patient prior to start of treatment). 3. Interferon Gamma Release Assay (IGRA) positive 4. Willing to comply with the study visits and procedures 5. Willing and able to provide written informed consent Exclusion Criteria: 1. Previous treatment for TB disease 2. Diabetes that is, in the judgment of the investigator, so poorly controlled that it would prevent adequate PET scanning 3. Cardiac pacemaker, aneurysm clip or other metallic implant considered unsafe for MRI 4. Occupation involving substantial exposure to radiation 5. Malignancy requiring chemotherapy or radiation 6. Known lung disease which may affect interpretation of the scan 7. Known chronic kidney disease 8. Symptoms, signs and/or previous investigations suggestive of active TB in the opinion of the investigator (cough for \>1 month, cough productive of sputum or blood, shortness of breath, weight loss, night sweats, fever, abnormal examination, chest X-ray findings) 9. Women who are currently pregnant or breastfeeding