Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma

Inclusion Criteria: * Cutaneous melanoma with Breslow depth \> 1 mm or melanoma Breslow depth of 0.76 - 1.00 mm in setting of ulceration, extensive regression * Mitotic rate \>= 1/mm\^2 * Presence of angiolymphatic invasion * Deep positive margin * No known allergies to contrast material Exclusion Criteria: * Pregnant or nursing * Patients with known cardiac shunt * Patients with class II heart failure or worse, per New York Heart Association (NYHA) classification * Patients who have experienced an acute coronary syndrome or angina in the past 6 months * Patients who have undergone coronary artery bypass grafting (CABG) or coronary stenting in the past 3 years * Patients with evidence of moderate or severe cardiac valvular disease on echocardiogram * Patients with evidence of moderate or severe pulmonary hypertension on echocardiogram * Patients with stage II chronic obstructive pulmonary disease (COPD) or worse, per Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification * Patients with hypersensitivity to sonazoid or one of its components * Patients with hypersensitivity to egg or egg products, because sonazoid contains a chicken egg-derived surfactant (hydrogenated egg phosphatidylserine sodium) * Patients who cannot consent for themselves