Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli

Tel Aviv University20 enrolled

Overview

The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Brain Activity Glucose Control

Interventions

StimulatorDEVICE

GlucoseDIETARY_SUPPLEMENT

300ml tap water with 75g glucose

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Age 18-65 years old. * Body mass index 18 to 25 kg/m2 * Capable of giving informed consent Exclusion Criteria: * Pregnancy, or nursing * Permanent pacemakers * Metal prosthesis * Skin disease * Claustrophobia * History of neurological disorders

Outcomes

Primary Outcomes

Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion.

Time frame: changes from baseline to 30 minutes after glucose ingestion

Central Contacts

Uri Nevo, PhD

CONTACT

972-3-6407542 nevouri@post.tau.ac.il

Data from ClinicalTrials.gov

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