Specimen Collection Study for H. Pylori Testing

Inclusion Criteria: * Aged 21 and to 75 years. * Able to read, speak, and understand English or have access to a translator in subject's native language. * Patients without prior H. pylori eradication treatment. * Currently not on proton pump inhibitors, antibiotics or bismuth * Discontinuation at least 2 weeks prior to endoscopy and specimen collection. * Present with signs and symptoms of dyspepsia \[e.g. upper abdominal discomfort or pain\] * Undergo gastric biopsies as part of routine care * Physician able to provide histology and rapid urease result on biopsy specimens. Exclusion Criteria: * Aged less than 21 years old or older than 75 years * Unable to provide consent. * Patients with a history of prior H. pylori eradication therapy. * Currently on proton pump inhibitors, antibiotics or bismuth and cannot or will not discontinue * Previous upper gastrointestinal surgery, such as bariatric surgery, Nissen fundoplication, or Roux-en-Y. * Any unstable or poorly-controlled medical or psychiatric condition.