Follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI\_MED-project (Greifswald Approach to Individualized Medicine). Standardized protocols will be used for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. Comparisons with the general background population will be performed.
5-year follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI\_MED-project (Greifswald Approach to Individualized Medicine). Subjects will be comprehensively phenotypes using standardized protocols for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. A multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of GANI\_MED. Comparisons with the general background population as characterized by the Study of Health in Pomerania (SHIP) will be performed.
Study Type
OBSERVATIONAL
Enrollment
1,200
no intervention, only observational
Department of Internal Medicine B, University Medicine Greifswald
Greifswald, Mecklenburg-Vorpommern, Germany
RECRUITINGCardiovascular events
Hospitalization (HF based. all-cause), myocardial infarction
Time frame: 1-year follow-ups
VO2peak
Exercise capacity by CPET
Time frame: 1-year follow-ups
QOL
Quality of life by questionnaire (Minnesota Living with heart failure questionnaire)
Time frame: 1-year follow-ups
6MW
6 minute walk test distance
Time frame: 1-year follow-ups
LVEF
Left ventricular ejection fraction by echo at time of follow-up
Time frame: 1-year follow-ups
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