Heparin Versus Saline in Peripheral Venous Catheter

Hospital General Universitario Gregorio Marañon354 enrolled

Overview

A clinical, prospective. controlled and randomized study with patients with a peripheral venous catheter. Patients will be randomized to either receive heparin or saline. The investigators will monitored the clinical out come to further evaluate catheter colonization rate, phlebitis rate, days of hospital stay, antimicrobial costs, and adverse effects.

The need of use of peripheral venous catheters and the importance of a proper management to avoid catheter colonization or phlebitis requires two possible preventive approaches: lock therapy with heparin or saline. Heparin demonstrated its efficacy in central venous catheters, but there are still controversies of whether it is useful in peripheral venous catheters. Objectives To compare the efficacy of heparin in peripheral venous catheters lock versus saline for the prevention of colonization and phlebitis in patients admitted to an Internal Medicine Department. Methods: A clinical, prospective. controlled and randomized study with patients with a peripheral venous catheter. Patients will be randomized to either receive heparin or saline. The investigators will monitored the clinical out come to further evaluate catheter colonization rate, phlebitis rate, days of hospital stay, antimicrobial costs, and adverse effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

354

Conditions

Catheter-Related Infections

Interventions

salineDEVICE

catheter lock using saline

HeparinDEVICE

catheter lock using Heparin

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with inserted PV Catheter within 24h from admission in internal medicine Exclusion Criteria: * hypersensibility to heparin * active hemorrhage * coagulation alterations

Locations (1)

Internal Medicine Department HGU Gregorio Marañón

Madrid, Spain

Outcomes

Primary Outcomes

complications

prevention of colonization(superficial and tip culture) and phlebitis(visual inflammation of entrance of catheter insertion) .

Time frame: Daily from catheter insertion until catheter withdraw(estimated 10 days)

Secondary Outcomes

catheter related infection rate

episodes of catheter related infection against number of days of exposure to catheter

Time frame: Through study completion( estimated 2 year after Last patient in)

adverse events(number of catheter obstructions and coagulation alterations)

Time frame: Through study completion (2 year afterLast patient in)

Data from ClinicalTrials.gov

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