Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery

University Hospital, Clermont-Ferrand12 enrolled

Overview

The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.

Colonic colonization by pathogenic Escherichia coli was determined when patients were operated on for colorectal cancer. Several years later, the investigator investigate past and actual psychiatric disorder using the Mini International Neuropsychiatric Interview (MINI). Actual depression and anxiety scores are evaluated with Hamilton scales and personality traits are investigated using Personality Inventory for DSM-5 (PID-5). Anxiety and depression scores, psychiatric diagnoses (MINI) and personality traits were compared in patients according to Escherichia coli presence/absence.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Colorectal Cancer

Interventions

Psychiatric evaluationOTHER

The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients operated on for colorectal cancer in the digestive surgery department of Clermont-Ferrand hospital * patients older than 18 years, * patients whose Escherichia coli colonization was analyzed after surgery * patients which are always followed by the digestive surgery department. Exclusion Criteria: * Patients with dementia will not be included, according to the MMSE score: * 22 if no grade * 23 if study certificate or CAP or college without patent * 25 if patent or school without the tray * 26 or more when bin

Locations (1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

Outcomes

Primary Outcomes

Hamilton anxiety and depression score comparison

Hamilton anxiety and depression score will be compared between patients with Escherichi coli colonic colonization and patients without Escherichi coli

Time frame: at day 1

Secondary Outcomes

Psychiatric prevalence comparison

prevalence of each past and actual psychiatric disorder diagnosed by the Mini International Neuropsychiatric Interview (MINI: major depression, dysthymia, suicidal risk, hypomania, mania, panic disorder, agoraphobia, social phobia, specific phobia, obsessive-compulsive disorder, posttraumatic stress disorder, dependence and abuse of alcohol, tobacco- dependence, psychotic disorders and generalized anxiety disorder) will be compared in patients according to colonic colonization by Escherichia coli.

Time frame: at day 1

personality traits comparison

personality traits investigated using Personality Inventory for DSM-5 (PID-5) will be compared in patients according colonic colonization by Escherichia coli

Time frame: at day 1

Data from ClinicalTrials.gov

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