The investigators perform a prospective, randomized, clinical study involving students in education with mood disorders and randomized to an intensive exercise program or a control relaxation activity.
The investigators wish to document the benefit of an intensive and structured exercise program in youth with the aim to identify the most effective programs that can improve psychological well-being, especially reducing depressive and anxiety symptoms and improving self-esteem. This study targets participants aged 9 to 30 years and included in an education program (from 4th Grade to undergraduate university or college). The investigators propose to perform a prospective, randomized, clinical study involving participants with mood disorders (International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) for medical coding: ICD-10-CM F32.9), anxiety (ICD-10-CM F41.9), specific learning disabilities (ADHD hyperactivity (ICD-10-CM F90.2), dyslexia-dyscalculia-dyspraxia (ICD-10-CM F81.0, F81.2, F81.81)) and healthy subjects equally distributed for confounding variables (age, gender, subclinical or clinical depressive symptoms). The participants (ambulatory or inpatients) will be enrolled either in an experimental, intensive and structured aerobic exercise regime or in a active control activity of stretching and relaxation conducted in parallel. The effects of this program will be assessed for i) psychological symptoms, using questionnaires, ii) cognitive function, particularly attention skills and executive functions, in neuropsychological tasks, and iii) physical abilities (through physical testing). To investigate the therapeutic value of exercise in the prevention of depressive and anxiety symptoms and in the treatment of mood disorders in the young student is a necessity imposed by the current outbreak of depression among adolescents and young people at school. To promote the exercise medicine based on the level of evidence in this specific domain, rigorous experimental studies must be performed. Depending on the results, a medical imaging will be proposed to participants at the end of the behavioral study. This will be a functional magnetic resonance imaging in physiological activation condition (performing a behavioral task such as a Stroop task suited to the subject's age), performed before and after intensive physical training.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
Moderate to high intensity physical training
Low intensity physical activity and relaxation
Université catholique de Louvain
Brussels, Belgium
RECRUITINGChange from baseline psychological well-being as assessed using depression and anxiety questionnaires
Hospital Anxiety Depression Scale (HADS) in french version for all participants, mainly suitable for inpatients
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline psychological well-being as assessed using self-esteem, mood and anxiety questionnaires
State-Trait Anxiety Inventory (STAI) in french version for all participants, mainly suitable for outpatients
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline psychological well-being as assessed using depression questionnaires for children
Children's Depression Inventory (CDI) in french version
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline psychological well-being as assessed using depression questionnaires for adolescents and adults
Beck Depression Inventory (BDI-13) in french version
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline psychological well-being as assessed using depression questionnaire for young people and adults
Self-depression scale (SDS) in french version
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline psychological well-being as assessed using self-esteem questionnaires
Self-perception profile for children or adolescents in french version
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
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Change from baseline physical condition : size
Height in meters
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline physical condition : weight
Weight in kilograms
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline physical condition as assessed in bioelectrical impedance analysis
Body mass index (BMI) in kilograms divided by the square of the height in meters (kg/m2)
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline physical condition : body muscle ratio
Body muscle percentage : {body muscle mass (kg) / total body mass (kg)} x 100
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline physical condition : body fat ratio
Body fat percentage : {body fat mass (kg) / total body mass (kg)} x 100
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline physical condition as assessed using field running tests or a cycle ergometer
An estimation of maximal oxygen consumption in field running test (20m-beep test). A submaximal effort test using a cycle ergometer.
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline cognitive function as assessed using computerized neuropsychological testing of cognitive control
Attention and conflict resolution testing using a variant of the Eriksen Flanker task, adapted for age, in E-Prime.
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months
Change from baseline cognitive function as assessed using computerized neuropsychological testing of inhibitory control
Inhibitory control testing using a go-no go test adapted in E-Prime.
Time frame: at 3 weeks, at 6 weeks and through study completion, up to 6 months