Recovery of the cognitive functions and recovery features after general anaesthesia in Down syndrome patients. A comparison of Sevoflurane and Desflurane.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
39
Gkliatis Emmanouil
Athens, Greece
Change in Cognitive Functions
Quantitative result measured by Prudhoe Cognitive Function Test (PCFT), a scale to assess cognitive function in adults with Down's syndrome.
Time frame: Baseline (12 to 24 hours before surgery), 1,5 hours after surgery and 4 hours after surgery
Spontaneous breathing
Time frame: Interval between discontinuation of inhaled agent and first spontaneous breath and up to 1 hour.
Eye opening
Time frame: Interval between discontinuation of inhaled agent and first eye opening and up to 1 hour.
Extubation
Time frame: Interval between discontinuation of inhaled agent and extubation and up to 1 hour.
Orientation
Time frame: Interval between discontinuation of inhaled agent and orientation in place, time, people and up to 1 hour.
Respond to commands
Time frame: Interval between discontinuation of inhaled agent and respond to commands and up to 1 hour.
modified Aldrete Scoring System (mASS)
Time frame: Interval between entrance in Post Operative Care Unit (PACU) and fulfillment of the criteria mASS to discharge PACU and up to 2 hours.
Orientation in PACU
Orientation in place, time and people in Post Operative Care Unit (PACU).
Time frame: 30 minutes after PACU entrance
Orientation in PACU
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Orientation in place, time and people in Post Operative Care Unit (PACU).
Time frame: 60 minutes after PACU entrance
Antiemetics necessity.
Note if additional antiemetics was needed up to 4 hours postoperatively.
Time frame: Interval between entrance in PACU and administer antiemetic medication and up to 4 hours.
Painkillers necessity.
Note if additional painkillers was needed up to 4 hours postoperatively.
Time frame: Interval between entrance in PACU and administration of antiemetic medication and up to 4 hours.
Patient Alertness, Wellness, Energy
Assessment of the accompanying persons.
Time frame: Baseline, 12 to 24 hours before surgery
Patient Alertness, Wellness, Energy
Assessment of the accompanying persons.
Time frame: 1,5 hours after surgery
Patient Alertness, Wellness, Energy
Assessment of the accompanying persons.
Time frame: 4 hours after surgery
Patient satisfaction over anaesthesia.
Assessment of the accompanying persons.
Time frame: 4 hours after surgery
Postanesthesia Discharge Scoring System (PADSS)
Time frame: Fulfillment of the criteria of PADSS from discontinuation of inhaled agent and up to 1 day.