Salt Intake and Lactobacillus Abundance

Charite University, Berlin, Germany8 enrolled

Overview

To investigate the influence of an increased salt intake (6 g/d for 14 days) on the relative abundance of gut lactobillus species in healthy men

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy Volunteers Probiotics Sodium

Interventions

ProbioticsDIETARY_SUPPLEMENT

Day 1-21: 2 capsules per day

SaltDIETARY_SUPPLEMENT

Day 8-21: 10 tablets à 600 mg per day

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men * 18 - 50 years * Body mass index 18,5 - 29,9 kg/m2 Exclusion Criteria: * Clinically relevant heart, lung, liver, and kidney disease * Current or chronic infections * Habitual intake of probiotics or dietary supplements

Locations (1)

Experimental and Clinical Research Center

Berlin, Germany

Outcomes

Primary Outcomes

Decrease of relative abundance of four lactobacillus species

Time frame: 14 days

Secondary Outcomes

Increase of systolic blood pressure

Time frame: 14 days

Increase of pulse wave velocity

Time frame: 14 days

Increase of lymphocytic pro-inflammatory mediators

Time frame: 14 days

Data from ClinicalTrials.gov

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