The investigator designed this study to investigate remifentanil effect-site concentration in 95% of patients (EC95) for preventing cough after laryngomicrosurgery from propofol anesthesia.
At the end of the surgery, propofol infusion was stopped and remifentanil was titrated to predetermined (initial concentration 1.0 ng/ml for the first patient). Extubation was performed when the patients opened their eyes and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
The concentration of remifentanil was determined by biased-coin up and down design, starting from 1.0 ng/ml (0.4 ng/ml as a step size)
Anesthesia was induced with propofol target-controlled infusion at an effect-site concentration of 5.0 μg/ml.
Ajou University Hospital
Suwon, Gyeonggi-do, South Korea
Number of cough
Number of cough or a strong and sudden contraction of the abdomen during periextubation periods
Time frame: from end of surgery to 5 min after tracheal extubation
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