The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale

Zhang Xiangyu50 enrolled

Overview

This study evaluates the effect of external diaphragmatic pacemaker on the patients with chronic cor pulmonale. Half of participants will receive external diaphragmatic pacemaker, while the other half will receive routine therapy.

Investigate the effect of external diaphragmatic pacemaker on chronic cor pulmonale, the indicators include: respiratory muscle force, diaphragmatic degree of excursion and thickness, pulmonary artery pressure, respiratory distress, feeling of fatigue and quality of life, pulmonary function,NT-proBNP,PaO2 and PaCO2.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Chronic Cor Pulmonale

Interventions

external diaphragmatic pacemaker groupDEVICE

9 counts per minute, with stimulate frequency 40 Hz

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of chronic cor pulmonale and admit to hospital Exclusion Criteria: * pneumothorax or mediastinal emphysema * active tuberculosis * install a cardiac pacemaker * acute cardiocerebrovascular events: acute myocardial infarction, acute myocarditis, severe arrhythmia, severe cerebrovascular accidents. * pregnancies * end-stage patients (expected survival time less than 6 months)

Locations (1)

Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

cardiopulmonary function

six miunte walk test

Time frame: 10 days

Secondary Outcomes

MIP

MAX INSPIRATORY PRESSURE

Time frame: 10 DAYS

Data from ClinicalTrials.gov

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