Apatinib for Esophageal Squamous Cell Cancer After the Failure of Standard Treatment

Inclusion Criteria: 1. Male or female patients, age:18-75 years old. 2. The ECOG physical status score: 0 to 2. 3. Confirmed by histology of recurrent or metastatic esophageal squamous cell carcinoma. 4. Patients who previously received at least fluorouracil, platin or taxane-based palliative chemotherapy but failed(including patients who developed disease progression within half of a year after finishing their adjuvant or neoadjuvant chemotherapy) and patients who are intolerable or refuse to receive chemotherapy of agents mentioned above and develop disease progression within 2 months. 5. Never received treatment of apatinib or any other anti-angiogenesis agent, such as sorafenib, sunitinib, bevacizumab, endostar etc. 6. Lesions can be measured at single diameter by thoracic or abdominal computed tomography (CT) or magnetic resonance (MRI).Conventional methods should set at least 20mm as diameter or spiral CT 10 mm. Patients with increased or new lesions in radiotherapy area can be enrolled in the trial. 7. Expected survival ≥ 3 months. 8. If the subject have received surgery, the operative wound should be completely healed and without bleeding tendency. 9. Baseline of blood routine and biochemical routine should meet the following criteria: * ANC≥1.5×10\^9/L（1500/mm3） * PLT≥75×10\^9/L * Hb≥9 g/dL * Serum bilirubin levels no higher than 2 times the upper limit of normal value. * AST and ALT no higher than 2.5 times the upper limit of normal value(no higher than 5 times the upper limit of normal value when patients developed liver metastasis). * Serum creatinine no higher than 1.5 times the upper limit of normal value. 10. No malabsorption or other gastrointestinal disorders that will affect drugs absorption. 11. No severe complications such as active digestive tract hemorrhage, perforation, jaundice, gastrointestinal obstruction, non-cancerous fever \> 38 ℃. 12. Patients should be voluntary to the trial and provide with signed informed consent. 13. Patients should have good compliance and cooperate with the evaluation of efficacy and adverse events and follow-ups according to the research plan. Exclusion Criteria: 1. Evidence of gastrointestinal bleeding tendency including: local active ulcer lesions with occult blood (+ +); melena and haematemesis within 2 months; possibilities of digestive tract hemorrhage. 2. Evidence of hypertension that could not be controlled by drugs (SBP\>140 mmHg, DBP\>90 mmHg), grade I coronary heart disease, grade I arrhythmia(including QT interval prolonged by 450ms in male and 470ms in female) and grade I heart failure. 3. Evidence of severe postoperative complications including intestinal obstruction, anastomotic fistula, pancreatic fistula and anastomotic stenosis. 4. Evidence of urine protein ≥ (++) and 24 hours urinary protein quantitation \>1.0 g. 5. Fractures unhealed for long term or incompletely healed. 6. Evidence of immunodeficiency disease, or other acquired or congenital immunodeficiency disease, or organ transplantation. 7. Evidence of coagulation disorders (INR\>1.5, APTT\>1.5 ULN), bleeding tendency(INR should be in normal value without anticoagulation 14 days before randomization), usage of anticoagulation or Vit K antagonist including warfarin, heparin or any other analogue. When INR≤ 1.5, small dosage of warfarin(1 mg p.o, qd) or Aspirin (dosage \< 100mg/d) in preventive purpose is allowed. 8. Evidence of arterial/venous thrombotic events within 1 year before inclusion, including cerebrovascular accident (including TIA), deep vein thrombosis( vein thrombosis caused by venous catheterization in previous chemotherapy is excluded) and pulmonary embolism. 9. Known severe hypersensitivity to Apatinib or any of the excipients of this product 10. Severe systemic disease out of control such as unstable or uncompensated respiratory,cardiac,liver,renal diseases. 11. CNS metastases without radiotherapy and/or surgery. Patients with treated CNS metastases may participate in this trial,except for those who must receive hormone therapy and those whose prior hormone therapy for CNS metastases is less than 4 weeks. 12. psychiatric illness that would prevent the patient from giving informed consent 13. Patient has a concurrent malignancy or has a malignancy within 5 years of study enrollment, with the exception of nonmelanoma skin cancer or cervical carcinoma in situ 14. Patient is concurrently using other approved or investigational antineoplastic agent 15. Pregnant or lactating women