Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM

Karolinska Institutet10 enrolled

Overview

This is a pilot study to investigate whether patients at advanced age are fluid responders via a reversible fluid challenge, the passive leg raise test. This will be measured with a non-invasive cardiac output monitor, the LiDCO (LiDCO Hemodynamic monitoring) .

The intervention is as simple as a passive leg raise with measurement of effect on Stroke volume.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Stroke Volume Cardiovascular System Fluid Therapy

Interventions

Passive leg raiseOTHER

By tilting the patient's bed from sitting 45 degrees to supine with legs tilted up 45 degrees we recruit the blood volume in the legs and can measure a reversible fluid challenge on stroke volume.

Eligibility

Sex: ALLMin age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients ≥80 years of age, undergoing elective urologic surgical procedure Exclusion Criteria: * age \<80 years, severe aortic insufficiency, first case of the day on the operation program, unavailability of research personnel and contraindication to Lithium.

Locations (1)

Karolinska University Hospital

Huddinge, Sweden

Outcomes

Primary Outcomes

Assess passive leg raise responsiveness in spontaneously breathing aged patients.

Stroke volume changes in ml and as per cent change compared to baseline

Time frame: Within 1 minute of the intervention

Secondary Outcomes

Investigate whether there is an association between a positive response to passive leg raise on stroke volume and post spinal anesthesia.

Post spinal bloodpressure per cent change or 30 mmHg decrease

Time frame: 30 minutes

Data from ClinicalTrials.gov

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