Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas

Inclusion Criteria: * Signed Informed Consent Form * Age≥18 years * Histologically or cytologically confirmed recurrent high-grade glioma after concurrent or adjuvant chemoradiotherapy * Prior treatment with temozolomide * Must have evidence of PTPRZ1-MET fusion gene positivity from the results of molecular pre-screening evaluations * At least one measurable lesion as per RANO * No evidence of recent haemorrhage on baseline MRI of the brain * Stable or decreasing dose of corticosteroids within 5 days prior to the first dose * Major surgery within 4 weeks prior to first dose of PLB1001 * Previous anti-cancer and investigational agents within 4 weeks before first dose of PLB1001. If previous treatment is a monoclonal antibody, then the treatment must be discontinued at least 6 weeks before first dose of PLB1001 * Pregnant or nursing women * Involved in other clinical trials \<30 days prior to first dose * Prior therapy with gamma knife or other focal high-dose radiotherapy is allowed, but the patient must have subsequent histologic documentation of recurrence, unless the recurrence is a new lesion outside the irradiated field * Karnofsky performance status ≥ 50% Exclusion Criteria: * Previous or current treatment with a c-Met inhibitor or HGF-targeting therapy * The subject is unable to undergo MRI scan (e.g. has pacemaker) * Clinically significant, uncontrolled heart diseases： Unstable angina; History of documented congestive heart failure (New York Heart Association functional classification\> II); Uncontrolled hypertension defined by a Systolic Blood Pressure (SBP) ≥ 145 mm Hg and/or Diastolic Blood Pressure (DBP) ≥85 mm Hg; Arrhythmias. * Active peptic ulcer disease or gastritis * Adverse events from prior anti-cancer therapy that have not resolved to Grade ≤ 1, except for alopecia * Major surgery within 4 weeks prior to first dose of PLB1001 * Previous anti-cancer and investigational agents within 4 weeks before first dose of PLB1001. If previous treatment is a monoclonal antibody, then the treatment must be discontinued at least 6 weeks before first dose of PLB1001 * Pregnant or nursing women * Involved in other clinical trials \<30 days prior to first dose