Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation

Milton S. Hershey Medical Center2 enrolled

Overview

The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Tissue biomarkers of renal injury may provide a real-time indication of renal function and the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO. In these patients, traditional markers of kidney function (urine output and serum Creatinine level) do not accurately represent renal function.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Injury

Interventions

biomarker levelsOTHER

The level of the biomarker hyaluronic acid will be measured

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age more than 18 years * refractory or advanced cardiogenic shock prior to institution of VA-ECMO Exclusion Criteria: * History of chronic kidney disease prior to cardiogenic shock, as defined by estimated glomerular filtration rate (GFR) less than 60 mL per min * Cognitive impairment * Pregnant women * patient or surrogate is not fluent in English * Long-term immunosuppression

Locations (1)

Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Outcomes

Primary Outcomes

renal biomarker levels

Time frame: through VA-ECMO decannulation, an average of 3 weeks

need for continuous renal replacement therapy at hospital discharge (Yes/No)

The need for continuous renal replacement therapy at hospital discharge will be assessed using hospital medical records

Time frame: measured at hospital discharge, an average of 2-3 months following initial hospital admission

Data from ClinicalTrials.gov

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