Patients admitted for coronary artery bypass surgery taking antiplatelet medicine have an increased risk for bleeding. Present study aims to compare the platelet function in two patient groups using different types of heart-lung machine methods. It is assumed that one of the methods is superior verified by sensitive methods of testing platelet function.
Taking antiplatelet medication before cardiac surgery increases the risk for bleeding. The surgical procedure and the use of a heart-lung machine may disturb the function of platelets, why measures to protect the existing function of platelets are of prime concern. The present study aims to compare how two types of heart-lung machine methods influence platelet function in two groups of patients. The platelet function will be tested before, during and after surgery by the use of two independent methods.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Performing CPB with low dose heparin and coated equipment
Performing CPB with high dose heparin and uncoated equipment
Heart Centre Umeå University Hospital
Umeå, Sweden
Assessment of platelet function following cardiopulmonary bypass using platelet aggregometry
Included aggregometry tests: Multiplate and Rotem Platelet
Time frame: Test of platelet function will be analysed on arrival to the operating room, post cardiopulmonary bypass and on day 1 in the intensive care unit based on the area under the curve depited from the two employed aggremometers
Postoperative bleeding
Blood loss 24 hrs post surgery
Time frame: Postoperative bleeding 24 hrs
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