Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01

Inclusion Criteria: * ≥70 years * Esophageal or Esophagogastric cancer * Histologically proven squamous cell carcinoma or adenocarcinoma in patients staged as IIa-IVb (UICC 2002, IVb only with supraclavicular or celiac trunk lymph nodes metastasis) * Karnofsky performance status(KPS)≥ 70 and Charlson score ≤3 * No distant metastasis other than supraclavicular lymph nodes * No prior history of thoracic radiation * Patients must have normal organ and marrow function as defined below: Leukocytes: greater than or equal to 3,500 G/L; Platelets: greater than or equal to 100,000/mm3 .Hemoglobin:greater than or equal to 10g/L .Total bilirubin: within normal institutional limits; AST/ALT: less than or equal to 1.5 times the upper limit; Creatinine within normal upper limits * Informed consent Exclusion Criteria: * Patients with other cancer history except cervical carcinoma in situ and non-malignant melanoma skin cancer * With any distant metastasis out of regional lymphatic drainage or in liver,lung,bone,CNS,etc * History of allergic reactions attributed to similar chemical or biologic complex to S-1 * With esophageal fistula, perforation, cachexia prior to treatment * Uncontrolled illness including, but not limited to, active infection, symptomatic heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness * History of myocardial infarction within the past 6 months or history of ventricular arrhythmia * Pregnant or lactating females