Neoadjuvant Chemo-endocrine Therapy Versus Chemotherapy Alone in ER-positive, HER2-negative Breast Cancer

Inclusion Criteria: 1. Estrogen receptor-positive and HER2-negative breast cancer patients, with histological stage of IIa-IIIc. 2. Without previous chemotherapy or endocrine therapy. 3. ECOG scores of 0-2 points 4. With measurable and evaluable breast tumor pathologically confirmed as invasive ductal carcinoma 5. Age: 18-70 years 6. Lateral breast cancer 7. Normal or acceptable kidney, liver, cardiovascular, and bone marrow functions Exclusion Criteria: 1. Pregnant women or nursing mothers 2. With distant metastasis 3. With a history of malignant tumor or complicated with other malignant tumors in addition to breast cancer, except for non-melanoma skin cancer, in situ cervical cancer or other cured malignant tumor without the basis of recurrence for at least five years 4. With mental illness or other conditions affecting the patient compliance 5. With other serious diseases or medical conditions: 1. Congestive heart failure or unstable angina pectoris, myocardial infarction within 6 months before the enrollment, uncontrolled hypertension and uncontrolled high-risk arrhythmia considered by the investigator 2. Obvious neurological or psychiatric disorders, including psychosis, epileptic dementia and other diseases may affect the understanding and sign of the informed consent for 3. Uncontrolled acute infection 6. Concurrent use of other investigational drugs; or participating in other clinical trials involving investigational drugs within 30 days before this study 7. With allergic constitution and any known or suspected drug allergy 8. Not suitable for the trial considered by the investigator