Hospital-based Diabetes Prevention Study in Korea

Inclusion Criteria: 1. 30\<Age\<71 2. BMI≥23 kg/m2 3. '75g Oral glucose tolerance 2 hours after the test Blood glucose140\~199mg/dL' or 'Fasting Blood Sugar 110\~125 mg/dL' or 'HbA1c 5.7%\~6.4%' Exclusion Criteria: 1. Who diagnosed with Diabetes Mellitus or Who having Drugs for Diabetes Mellitus. 2. Type 2 Diabetes Mellitus * Who diagnosed with Diabetes Mellitus except for maternity period. * Who have had drugs for Diabetes Mellitus(hypoglycemic agent or insulin) except for maternity period. * Fasting Glucose≥ 126 mg/dL * 75g Oral glucose tolerance 2 hours after the Blood glucose ≥ 200 mg/dL * HbA1c ≥ 6.5% 3. Who life expectancy is short. * Cardiac history * History of severe cardiovascular disease within the last 6 months (cerebral hemorrhage, stroke, myocardial infarction, angina pectoris, heart failure, etc.) * Systolic blood pressure \>180 mmHg or Diastolic blood pressure \>105 mmHg * aortic stenosis * Left bundle branch block or Third degree AV block * Who had been diagnosed and treated for malignant tumors including leukemia and lymphoma within the last 5 years * Abnormal renal function (Creatinine ≥ 1.4 mg/dL (male) or ≥ 1.3 mg/dL (female) or Urine Protein ≥ 2 +) * Anemia(Hematocrit \<36%((male) or\>\<33%(female)) ⑤ Cirrhosis or chronic active hepatitis (AST/ALT\>３UNL) * Acute gastrointestinal disease (pancreatitis, infectious intestinal disease) * Who is scheduled major surgery within the last 3 to 6 months or just after the surgery. * Chronic infection (HIV, active tuberculosis, etc.) * Pulmonary patients who rely on oxygen or daily bronchodilators 4. Who is judged to be able to influence the clinical trial by investigator. * Who can not communicate * Those with psychiatric or cognitive impairment that may affect the compliance of the clinical trial * Those who do not agree to the treatment group allocation by random assignment * Those who participate in other studies that may interfere with the clinical trial * Those who lost weight by more than 10% during the past 6 months, excluding weight loss after giving birth * Those who can not have normal walking or exercise * Women who are pregnant * Those who are currently pregnant or who are within the last 3 months after giving birth * Those planning pregnancy during the clinical trial period * Those who have a history of drug and alcohol abuse (acute, chronic) within the last 2 years * Those who are not appropriate or unreliable for clinical trials at the discretion of the tester 5. Who taking medication or medical condition that may affect the diagnosis of diabetes * Thiazide diuretics * Systemic beta blockers * Taking Niacin for the treatment of neutropenic depression * Possibility of taking or injecting a systemic steroid preparation * Taking a serotonin reuptake inhibitor (SSRI) for weight loss purpose. * Taking medicine for weight loss * Hormone status is not appropriate during thyroid hormone replacement therapy (TSH abnormal range) (If thyroid hormone therapy is stable for more than 3 months and TSH is normal, the patient can participate in) * Others with other endocrine diseases (eg Cushing's syndrome, acromegaly) * During treatment, fasting plasma triglyceride\> 600 mg / dL