Management Strategy for Mild to Moderate Major Depression: Combination of Rhodiola and Saffron Extracts.

Inclusion Criteria: * Suffering from mild to moderate depression as defined in CIM-10 * Having a score on the HAM-D questionnaire between 8 and 18 * Having agreed to participate at the study after being informed by the investigator Exclusion Criteria: * Depressive patients already under medication or discontinuation of medication less than a month ago * Patients with severe depression as defined in CIM-10 or HAM-D\> 18 * Patients considered at risk: attempted suicide or suicidal (observed by the investigator or Hamilton item 3 score\> 2) * Patients with psychiatric disorders: schizophrenia, bipolarity, addiction (drugs, alcohol ...), etc. * Patient with severe disease (cancer, kidney or heart disease) or patient with a contra-indication for taking the product (patient under anti-hypertensive ...) * Patients using agents containing piperine or St. John's wort (interactions) * Pregnant or breastfeeding patients * Patients who do not wish to complement Phytostandard® Rhodiola - Saffron. * Patients who do not wish to participate in the study. * Patients unable to understand the ins and outs of the study (mental incapacity, language barrier).