CaptHPV : Validation of the Method "CaptHPV" for the Diagnosis of Human Papillomavirus Associated Infiltrating Carcinomas

Institut de Cancérologie de Lorraine100 enrolled

Overview

The current project is based on the assumption that a diagnosis of human papillomavirus associated Infiltrating Carcinomas can be made from a blood sample for patient with Cervical Cancer, Vulvar Cancer, Anal Cancer, Oropharynx Cancer, Oral Cavity Cancer or Penis Cancer at any stage of the disease and including surgical treatment for the small tumors.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Cervical Cancer Vulvar Cancer Anal Cancer Oropharynx Cancer Oral Cavity Cancer Penis Cancer

Interventions

CaptHPV methodOTHER

20 ml of blood sample will be made before the beginning of all treatment. This blood sample will be sent to the CERBA Laboratory for analysis. In parallel, a standard anatomopathological and virological analysis will be carried out from a biopsy or from a tumor sample by the Tumor Biology Unit at Lorraine Institute of Oncology The results of both analyzes will be compared blindly.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>18 years * Patient with cervical cancer, vulvar cancer, anal cancer, oropharynx cancer, oral cavity cancer or penis cancer * Patient naive of any treatment for this pathology * Patient capable and willing to follow all procedures of the study in accordance with the study * Ability to provide an informed written consent form * Affiliation to a social security system Exclusion Criteria: * Patients who have already undergone surgical treatment leading to complete removal of the lesions or who have started treatment with radiotherapy and / or chemotherapy * Patient whose health status contraindicates a blood sample of 20 ml, * Absence of informed written consent form * Pregnant or breast feeding females * Patients deprived of liberty or under supervision

Outcomes

Primary Outcomes

Assessement of CaptHPV method

The diagnostic value of the serum marker provided by the method CaptHPV will be assessed in sensitivity and specificity to results of histological and virological analyzes of a sample tumor.

Time frame: 1 day