Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia

University of British Columbia4 enrolled

Overview

Dystonia is increasingly being considered as a multi-nodal network disorder involving both basal ganglia and cerebellar dysfunction. The aim of this study is to determine if "Multi-Target" Thalamic and Pallidal Deep Brain Stimulation improves hemi-dystonia patients who are receiving inadequate therapy from GPi DBS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Dystonia Dystonia, Secondary

Interventions

Deep Brain StimulationDEVICE

Deep Brain Stimulation Electrode

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosed with hemi-dystonia secondary to stroke 2. Candidate for GPi DBS 3. Able to provide informed consent Exclusion Criteria: 1. History of intracranial pathology (such as multiple sclerosis, tumors, or aneurysms) that may account for dystonia or essential tremor. 2. History or evidence of ongoing psychiatric or neurodegenerative disorders (such as Parkinson's disease, Alzheimer's disease). 3. Incompetent adults or those unable to communicate.

Locations (1)

Vancouver General Hospital

Vancouver, British Columbia, Canada

RECRUITING

Outcomes

Primary Outcomes

Burke Fahn Marsden Disability Rating Scale (BFMDRS)

Time frame: 3 months

SF-36 Quality of Life Scale

Time frame: 3 months

Adverse effects of Vim or Vim + GPi Neuromodulation

Time frame: 3 months

Central Contacts

Chris Honey, MD,DPhil,FRCSC

CONTACT

604-875-5894 chris.honey@telus.net

Leah Polyhronopoulos, BSc

CONTACT

778-938-6127 leahpoly@mail.ubc.ca

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.