Prenatal Screening, Diagnosis and Intrauterine Intervention of Fetal Abnormal Chromosome and Structure in Twins Pregnancy

Shanghai First Maternity and Infant Hospital1,300 enrolled

Overview

The risk of abnormal chromosome and structure is much higher in twins than in singletons, and traditional early pregnancy screening strategy for single pregnancy is not suitable for twins. Based on our management experience of fetal medicine at twin pregnancy, and multi-center cooperation, the study will carry out the following clinical studies: 1. to explore a suitable, early, noninvasive and accurate prenatal screening strategy for twin pregnancy. 2. fetal chromosomal abnormalities

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

1,300

Conditions

Chromosome Abnormality Twin Pregnancy With Antenatal Problem

Interventions

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ultrasound diagnosis as twin pregnancy * at 11-14 gestational weeks Exclusion Criteria: * Multiple pregnancies (three or more) * Maternal history of chromosome aneuploidy abnormality or tumor

Outcomes

Primary Outcomes

Success rate for the operation

Time frame: 1 week

Secondary Outcomes

long-term complications after surgery

Time frame: 1 year