The aim of this prospective randomized double-blind study was to compare the efficacy of new pharmaceutical composition containing botulinum toxin injection in epicardial fat pads for preventing recurrences of atrial tachyarrhythmia in patients with paroxysmal atrial fibrillation undergoing coronary artery bypass grafting.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
180
State Research Institute of Circulation Pathology
Novosibirsk, Russia
RECRUITINGCardiology Research Institute
Tomsk, Russia
RECRUITINGFreedom from any atrial tachyarrhythmias
Recurrence of \>30 s of any atrial tachyarrhythmia, including atrial fibrillation and atrial flutter/tachycardia, after cardiac surgery procedure with no antiarrhythmic drug
Time frame: 12 months
number of deaths
Time frame: 12 month
time intervals from end of surgery to weaning from ventilation, extubation and discharge from ICU
Time frame: 1 month
incidence of congestive heart failure
Time frame: 12 month
incidence of sustained ventricular arrhythmias
Time frame: 12 month
stroke or transient ischemic attack
Time frame: 12 month
incidence of myocardial infarction
Time frame: 12 month
rehospitalization
Time frame: 12 months
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