Effect of Magnesium Supplementation for Children With Drug Resistant Idiopathic Epilepsy

Ain Shams University60 enrolled

Overview

Effect of oral magnesium sulfate (Mg) supplementation will be studied. Children with drug resistant idiopathic epilepsy following up in Pediatric Neurology Clinic, Ain Shams University, will be randomized to either Mg add-on treatment group or anti-epileptic drugs AEDs alone. Serum magnesium, seizure control and Intelligent quotation (IQ) will be done at base line and after 6 months of treatment.

The Aim of this work was to study the effect of Magnesium as add on therapy on clinical seizure control in drug resistant idiopathic epilepsy and IQ.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Drug Resistant Epilepsy

Interventions

MagnesiumDIETARY_SUPPLEMENT

Oral magnesium

Placebo - ConcentrateDRUG

Placebo will be given

Eligibility

Sex: ALLMin age: 6 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children with drug resistant idiopathic epilepsy Exclusion Criteria: * Structural, Metabolic, Infectious and Unknown etiology epilepsy * Any neurological disease other than epilepsy * Any nutritional disorder * Any other systemic diseases (including Renal disease, Cardiac arrhythmia) * Drug intake other than antiepileptic drugs (AED)

Locations (1)

Children's Hospital, Faculty of Medicine, Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

Seizure control

Change from base line seizure frequency, severity (Chalfont scale) at 6 months.

Time frame: 6 months

IQ improvement

Change from base line IQ (Wechsler Intelligence Scale-Revised for Children and Adults)

Time frame: 6-months

Data from ClinicalTrials.gov

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