Specific Respiratory Infections as Triggers of Acute Medical Events

University College, London787,000 enrolled

Overview

This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.

We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity. This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.

Study Type

OBSERVATIONAL

Enrollment

787,000

Conditions

Influenza, Human Respiratory Syncytial Virus Infections Parainfluenza Rhinovirus Adenovirus Human Metapneumovirus Pneumonia Cardiovascular Diseases

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years * Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age Exclusion Criteria: * Outcome events occurring in people aged \<45 years

Locations (1)

University College London (UCL)

London, United Kingdom

Outcomes

Primary Outcomes

Acute myocardial infarction

ICD-10 coded

Time frame: 01/01/2004 to 31/12/2014

Stroke

ICD-10 coded

Time frame: 01/01/2004 to 31/12/2014

Data from ClinicalTrials.gov

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