Total Antioxidant Capacity Before and After HRT in Hypotalamic Amenorrhea

Catholic University of the Sacred Heart20 enrolled

Overview

The aim of our study is to investigate the effects of 6 months oh HRT on total anti-oxidant capacity, clinical, endocrine and metabolic features in women affected by hypotalamic amenorrhea. The study group included 20 patients treated with 1 mg of transdermal estradiol daily and 10mg of oral Medroxyprogesterone acetate from 16th to 24th day of therapy for six months. Menstrual pattern, anthropometric parameters, hormonal assays, DXA and bone metabolism parameters are evaluated before and after therapy.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypothalamic Amenorrhea

Interventions

1 mg of transdermal estradiol daily and 10mg of oral MPADRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hypotalamic Amenorrhea Exclusion Criteria: * diabetes mellitus (or impaired glucose tolerance as determined by a standard 75 gr oral glucose tolerance test) * hypertension * significant liver or renal impairment * other hormonal dysfunction (hypothalamic, pituitary, PCOS, thiroidal or adrenal) * neoplasms

Locations (1)

Catholic university of Sacred Heart

Rome, Rome, Italy

RECRUITING

Outcomes

Primary Outcomes

Total Anti-oxidant Capacity

Time frame: 6 Month

Secondary Outcomes

Bone Mineral Density

Time frame: 6 Months

Osteocalcin

Time frame: 6 Months

Estrogen levels

Time frame: 6 Months

number of Cycles in 6 months

n° of menstrual cycle

Time frame: 6 Months

beta crosslaps

Time frame: 6 months

Data from ClinicalTrials.gov

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