Effect of Proton Pump Inhibitor and Mosapride on Acid Pocket in Gastroesophageal Reflux Disease

Inclusion Criteria: * Patients with diagnosed GERD(gastro-esophageal reflux disease), defined by the presence of oesophagitis obtained during a previous upper endoscopy or typical GERD symptoms(heartburn, acid reflux). Exclusion Criteria: * who had organic gastrointestinal disease including inflammatory bowel disease, cancer and ulcer * who took drugs which could affect evaluation of the treatment; other PPIs, H2RAs(H2 receptor antagonists), prokinetics,mucosal protective agents, antacids, cholinergic and anticholinergic agents, and antidepressants for at least 4 weeks prior to study start * who had severe systemic diseases including hepatic and nephrotic disease * who had previous gastrectomy history * who was in state of pregnancy