Peripheral Physiological Measures as Determinants of Pain Risk

Neuroscience Technologies SLP, Barcelona200 enrolled

Overview

This study evaluates peripheral nervous system function using Multiple Excitability Measures (MEM) to obtain "electrophysiological pain phenotypes"

Using MEM for peripheral sensory and motor axons we want to identify a set of excitability measures that: 1. Correlate with parameters of clinical pain and of pain processing in existing pain patients (cross sectional study), with the aim to obtain an objective Pain Biomarker. 2. Predict development of neuropathic pain in susceptible patients (longitudinal study). Neuropathic Pain Predictor for patients: i. Undergoing surgical procedures associated with a relatively high risk of developing neuropathic pain such as thoracotomy and hernia repair ii. Planning to start chemotherapy with potentially neurotoxic agents such as vincristine

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Polyneuropathies Peripheral Nerve Injuries Peripheral Nervous System Diseases Chemotherapy Effects Neuralgia

Interventions

Multiple Excitability Measures of peripheral nervesOTHER

The technique of threshold tracking can be used to obtain several measures of peripheral nerve excitability (Multiple Excitability Measures or MEM), such as refractoriness, supernormality, strength-duration time constant and 'threshold electrotonus' (i.e. the changes in threshold produced by long-lasting depolarizing or hyperpolarizing current pulses). Each of these measurements depends on membrane potential and on other biophysical properties of the axons. Many of these excitability parameters are very constant among different subjects, while other, such as the current/threshold parameters and the super/sub-excitability parameters, appear to be characteristic of an individual

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic peripheral neuropathic pain * Painless Patient with risk to develop neuropathic pain (post-surgery, chemotherapy-induced) Exclusion Criteria: * Minors

Locations (1)

Neuroscience technologies

Barcelona, Spain

RECRUITING

Outcomes

Primary Outcomes

Electrophysiological pain phenotypes using MEM. Pain biomarker

Correlate with parameters of clinical pain and of pain processing in existing pain patients

Time frame: Single assessment (cross sectional study) at the first and only visit

Electrophysiological pain phenotypes using MEM. Pain predictor

Predict development of neuropathic pain in susceptible patients

Time frame: Single assessment at baseline, before any procedure (surgery/chemotherapy)

Central Contacts

Romà Solà, MD

CONTACT

0034 934020164 rsola@nsc-tec.com

Data from ClinicalTrials.gov

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