Studies of the Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine

Inclusion Criteria: * Healthy volunteer between 60-90 days old, 6-12 years old, or 18-49 years old; * Healthy volunteers who fulfill all the required conditions for receiving the investigational vaccine as established by medical history and clinical examination and determined by investigators; * Proven legal identity; * Participants (≥ 18 years old), or guardians of the participants (\< 18 years old) should be capable of understanding the written consent form, and such form should be signed prior to enrolment; * Complying with the requirement of the study protocol; * Axillary temperature ≤ 37.0 °C; Exclusion Criteria: * Breast feeding, pregnant, or expected to conceive in the next 60 days; * History of allergy to any vaccine, or any ingredient of the vaccine, or serious adverse reaction(s) to vaccination, such as urticaria, dyspnea, angioneurotic edema, abdominal pain, etc; * Congenital malformation, developmental disorders, genetic defects, or severe malnutrition; * Autoimmune disease or immunodeficiency/immunosuppressive; * serious chronic diseases, serious cardiovascular disease, hypertension or diabetes that cannot be stabilized by medication, liver or kidney disease, malignancy, etc; * severe nervous system disease (epilepsy, seizures or convulsions) or mental illness; * History of thyroidectomy, asplenia, functional asplenia, or any condition resulting in the absence or removal the spleen; * Bleeding disorder diagnosed by a doctor (e.g., coagulation factor deficiency, coagulation disorder, or platelet disorder) , or significant bruising or coagulopathy; * Long term history of alcoholism or drug abuse; * Receipt of any of the following products: 1. Any subunit or inactivated vaccine within the past 7 day; 2. Any live attenuated vaccine within the past 14 days; 3. Any other investigational medicine(s) within the past 30 days; 4. Any blood product within the past 3 months; 5. Any immunosuppressant, cytotoxic medications, or inhaled corticosteroids (except corticosteroid spray for treatment of allergic rhinitis or corticosteroid treatment on surface for acute non-complicated dermatitis) within the past 6 month prior to study entry; * Acute illness or acute exacerbation of chronic disease within the past 7 days; * Axillary temperature \> 37.0 °C; * Infant participants with prior vaccination of poliovirus; * Any other factor that, in the judgment of the investigator, suggesting the volunteer is unsuitable for this study;