Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
26
Brain perfusion
MRI - arterial spin labelling
Time frame: Change from baseline to 12 weeks dietary supplementation
Brain activation
fMRI whilst performing modified Stroop task
Time frame: Change from baseline to 12 weeks dietary supplementation
Cognitive function tests
Cogstate battery of tests
Time frame: Change from baseline to 12 weeks dietary supplementation
Blood biomarkers of inflammation
CRP, IL6,
Time frame: Change from baseline to 12 weeks dietary supplementation
Blood biomarkers of oxidative stress
protein carbonyls, glutathione
Time frame: Change from baseline to 12 weeks dietary supplementation
Blood biomarkers of neurogenesis
BDNF
Time frame: Change from baseline to 12 weeks dietary supplementation
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