Corticosteroid Rhythms in Hypoparathyroid Patients

Inclusion Criteria: * Postsurgical hypoparathyroidism of at least one year duration. Undetectable PTH values (\< 0.3 pmol/l) or less than 1.3 pmol/l despite hypocalcaemia (Reference range PTH: 1.3-6.8 pmol/L) must be documented before inclusion. 25-hydroxyvitamin D (25(OH)D) should be \> 50 nmol/l prior to baseline. * Healthy male and female volunteers, aged 18-60 years * Patients with primary hyperparathyroidism, defined as simultaneous increased PTH and serum calcium levels, normal or increased urine calcium to exclude hypocalciuric hypercalcemia, normal kidney function (estimated glomerular filtration rate (eGFR) above 60), aged 18-60 years Exclusion Criteria: * Patients with diabetes mellitus, Addison's disease and patients on steroid medication will not be included in this study. * Other exclusion criteria are unstable cardiovascular disease, active malignant disease, epilepsy, pregnancy or lactation, significant hepatic or kidney disease (alanine aminotransferase (ALAT) and or aspartate aminotransferase (ASAT) \> 2 times upper limit of normal, eGFR \< 30 ml/min), pharmacological treatment with PTH the last 3 months, treatment with other drugs that could interfere with interpretation of the results. Allergy to metacresol, lidocaine or multiple allergies.