The investigators hypothesize that transcranial direct current stimulation (tDCS) can improve upper limb motor recovery in the sub-acute phase of stroke patients. This is a randomized, controlled, double blind, cross-over, multicentre, clinical trial.
The investigators hypothesize that transcranial direct current stimulation (tDCS) can improve upper limb motor recovery in the sub-acute phase of stroke patients. This is a randomized, controlled, double blind, cross-over, multicentre, clinical trial. Informed consent was obtained from all participants and procedures were conducted according to the Declaration of Helsinki. The protocol was approved by the Chonbuk National Uni. Hospital IRB, KOREA. Seventy-two stroke patients in the sub-acute phase will be recruited in three centers of neurorehabilitation in republic of Korea. Patients will be randomly divided to four groups; group1 is anodal stimulation on the lesioned primary motor cortex, group 2 is cathodal stimulation on the non-lesioned primary motor cortex, group 3 is dual stimulation such as anodal stimulation on the lesioned side and cathod stimulation on the non-lesioned side, and group 4 is shame stimulation group. The stimulation will be conducted 2mA for 20 minute a day, 5 days per weeks, totally 2 weeks. Fugl-Meyer upper motor score will be measured as a primary outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
DOUBLE
Enrollment
72
2mA for 20minutes a day, 5 days per weeks, totally 2 weeks
Kim Yeon Hee
Seoul, Ilwon, South Korea
RECRUITINGFugl-Meyer Upper Motor Score change
Time frame: before treatment, 48 hours after treatment, 4 weeks after treatment
Manual Muscle Test (MMT) change
Time frame: before treatment, 48 hours after treatment, 4 weeks after treatment
Range of Motion (ROM) change
Time frame: before treatment, 48 hours after treatment, 4 weeks after treatment
Korean version Modified Bathel Index (KMBI) change
Time frame: before treatment, 48 hours after treatment, 4 weeks after treatment
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