Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay

Inclusion Criteria: 1. 18 years or older 2. A positive blood culture 3. A suitable residual blood sample collected within 24 hours of the positive blood culture OR 4. A blood sample obtained for the study obtain within 48 hours of the positive blood culture For Endocarditis Cohort: 1\. All criteria above must be met and patient is admitted to the hospital and evaluated for acute endocarditis classified per the Duke Criteria Exclusion Criteria: 1. Inability to understand instructions and comply with study-related procedures 2. Any condition that in the opinion of the treating physician will prevent the subject from completing the study