Comparison of Laser Assisted Epidermal to Intradermal Administration of Seasonal Influenza Vaccine

Inclusion Criteria: * Written informed consent * 18-30 years old (male or female), * Photo type I to IV (according to Fitzpatrick scale), * Subject must be willing and able to comply with study protocol for the duration of the study, * Females of childbearing potential (FCB) must maintain reliable contraception throughout the study. Exclusion Criteria: * Known pregnancy or positive pregnancy test for women of child bearing potential, * Positive screening assessment for human immunodeficiency virus or viral hepatitis (Hepatitis B or Hepatitis C) * Known or suspected immune dysfunction that is caused by a medical condition, or any other cause and that would interfere with the conduct of the study, * Use, within the past 3 months, of any topical or systemic treatment that would interfere with assessment and/or investigational treatment (anti-inflammatory drugs, immune suppressors or any immune modulator agent), * Use of any topical treatment on the injection site within the last four weeks, * Photo type V and VI (according to Fitzpatrick scale), * Skin lesions or excessive hair growth at treatment site, * Any history of seasonal influenza in the past 6 months, * Any seasonal influenza vaccine in the past, * Preexisting HAI antibody titers of \>40 against more than one influenza strain included in the vaccine, * Acute illness or febrile illness (over 37,5°C) within one week prior to enrollment, * Hypersensitivity to elements of the influenza vaccine (e.g. egg), * Administration of any live vaccine (\< 28 days) or inactivated/toxoid vaccine (\< 14 days) or planned vaccination within 3 months after inclusion, * Medical history of skin cancer, * History of Guillain Barre syndrome or brachial neuritis following previous vaccination, * Any history of having blood transfusions or administration with gamma globulin in the past 3 months * Women of childbearing potential not actively practicing birth control or using medically accepted device or therapy, * Subject being judged as inadequate for following the procedures of the trial by investigator, * Participation in another clinical trial (including follow up phase of a previous clinical trial)