Evaluation of a Probiotic (Bifidobacterium in the Treatment of Infantile Colic (IC)

Inclusion Criteria: * exclusively breastfed healthy infants of both sex, aged ≤ 7 weeks; * Diagnosis of IC according to Rome III criteria * Written informed consent of the parent/tutor Exclusion Criteria: * Birth weight\<2500 g * Gestational age\<37 weeks * APGAR 5 minutes \<7 * Formula feeding * Abnormal body growth/loss of weight (\<100 g/weeks from birth to the last reported weight) * Neurological diseases * Known or suspected food allergy * Gastroesophageal reflux disease * Use of substances that alter gut microbiota (pre/pro/synbiotic, antibiotics, gastric acidity inhibitors) or any anti-colic drug in the last 2 weeks prior the enrollment * History of fever and/or infectious diseases in the last 2 weeks prior the enrollment * Ongoing systemic infections * History of congenital infections * Chronic intestinal diseases (cystic fibrosis or other forms of pancreatic insufficiency primitive) * Malformation of the gastrointestinal (such as esophageal atresia, intestinal atresia, short bowel syndrome, malrotation), urinary or respiratory tract * Metabolic diseases * Genetic diseases and chromosomal abnormalities * Primary or secondary immunodeficiencies * Not sufficient reliability or presence of conditions that may result in non-compliance/adherence of the patient to the Protocol * Previous participation in this study