The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and behavioral measures as collected in children aged 9-10 years, either born preterm or full-term.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
150
Inhibition training on a tactile tablet for a month (20 sessions of 15 min)
Working memory training on a tactile tablet for a month (20 sessions of 15 min)
Mindfulness training on a tactile tablet for a month (20 sessions of 15 min)
GIP Cyceron
Caen, France
RECRUITINGChange in brain functional BOLD activity after one month of executive training as assessed by MRI in regions subtending executive functioning.
Change in brain activation will be measured with functional magnetic resonance imaging (fMRI) during two different tasks: a Stop Signal task assessing inhibition and a Dot task assessing working memory.
Time frame: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Change in brain cortical structure after one month of executive training as assessed by anatomical MRI in regions subtending executive functioning.
Change in brain cortical structure will be measured with anatomical magnetic resonance imaging (aMRI) using four different measures: 2.a. grey matter volume 2.b. cortical thickness 2.c. cortical surface area 2.d. curvature
Time frame: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Change in cognitive behavioral measures after one month of executive training as assessed by cognitive testing
The cognitive testing session includes several tasks assessing executive functioning under different conditions. Will be investigated: 3.a. Response Time 3.b. Accuracy
Time frame: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Sulcal morphometry measured by anatomical MRI
Assessing the impact of the early determined sulcal morphometry on behavioral and brain changes associated to a one-month executive training.
Time frame: Pretest (t0)
Genetic variations measured by Single Nucleotide Polymorphism (SNP) genotyping
Assessing the impact of the different genotypes on behavioral and brain changes associated to a one-month executive training.
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Active control training on a tactile tablet for a month (20 sessions of 15 min)
Collection of a saliva sample for genotyping
Structural and functional MRI
Battery of cognitive and academic tasks on executive functions
Time frame: Pretest (t0)