Effects of Two Herbal Dietary Supplements on Lipid Metabolism in Moderate Hypercholesterolemia and Hypertriglyceridemia

Inclusion Criteria: * Age between 18 and 70 years (limits included), * BMI between 18.5 and 40 kg/m2 (limits included), * For women: Non menopausal with the same reliable contraception since at least 3 cycles before the beginning of the study and agreeing to keep it during the entire duration of the study (condom with spermicide gel and estrogen/progestin combination contraception accepted) or menopausal without or with hormone replacement therapy (estrogenic replacement therapy begun from less than 3 months excluded), * Weight stable within ± 5 % in the last three months, * Non smoking or with tobacco consumption \< 20 cigarettes / day, * Good general and mental health with in the opinion of the investigator: no clinically significant and relevant abnormalities of medical history or physical examination, * Able and willing to participate to the study by complying with the protocol procedures as evidenced by his dated and signed informed consent form, * Affiliated with a social security scheme, * Agree to be registered on the volunteers in biomedical research file. After V1 biological analysis the subjects will be eligible to the study on the following criteria: * Fasting blood LDLc level (using Friedewald estimation method) between 1.3 and 2.2 g/L (limits included with ± 2 % tolerated around), * Fasting blood triglycerides level \> 1.5 g/L, * Blood TSH level between 0.27 and 4.2 μIU/mL (limits included). Within 3 months following to the exit of the study for failure to comply to one or more of the inclusion criteria listed above, a re-screening could be performed. Exclusion Criteria: * Suffering from a metabolic disorder such as diabetes, uncontrolled thyroidal trouble or other metabolic disorder, * Suffering from a severe chronic disease (e.g. cancer, HIV, renal failure, hepatic or biliary disorders ongoing, chronic inflammatory digestive disease, arthritis or other chronic respiratory trouble, etc.) or gastrointestinal disorders found to be inconsistent with the conduct of the study by the investigator (e.g. celiac disease), * With a history of ischemic cardiovascular event, * Having undergone recent surgical procedure (less than 6 months), * Suffering from an uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg), * With a known or suspected food allergy or intolerance or hypersensitivity to any of the study products' ingredient, * Pregnant or lactating women or intending to become pregnant within 3 months ahead, * For women: pregnancy or breastfeeding finished since less than 6 months, * Under cholesterol and/or lipid-lowering treatment (e.g. statins, fibrates, ezetimibe, bile acid sequestrants, niacin, etc.) or stopped less than 3 months before the V1 visit, * Requiring a cholesterol lowering by immediate pharmacologic intervention according to the current recommendations (AFSSAPS, 2005), * Under medication which could affect blood lipid parameters (e.g. long-term corticosteroid systemic drug, systemic antibodies, androgens or enzyme inducer, etc.) or stopped less than 3 months before the randomization (antihypertensive stable long-term treatment tolerated), * Regular intake of dietary supplements or "functional foods" which are known to have an impact on lipid metabolism (e.g. rich in plant stanol or sterol like PRO-ACTIV or DANACOL products, red yeast rice, policosanol, capsules containing omega-3 fatty acids from fish oils, containing beta glucanes, konjac extract or cinnamon, etc.) or stopped less than 3 months before the V1 visit, * Under treatment or dietary supplement which could significantly affect parameter(s) followed during the study according to the investigator or stopped in a too short period before the V1 visit, * With significant change in food habits or in physical activity in the 3 months before the V1 visit or not agreeing to keep them unchanged throughout the study, * With a current or planned in the next 3 months specific diet (hyper or hypocaloric, vegan, vegetarian...) or stopped less than 3 months before the study, * With a personal history of anorexia nervosa, bulimia or significant eating disorders according to the investigator, * Consuming more than 3 standard drinks of alcoholic beverage daily for men or 2 daily for women or not agreeing to keep his alcohol consumption habits unchanged throughout the study, * Having a lifestyle deemed incompatible with the study according to the investigator including high level physical activity (defined as more than 10 hours of significant physical activity a week, walking excluded), * Who made a blood donation in the 3 months before the V1 visit or intending to make it within 3 months ahead, * Taking part in another clinical trial or being in the exclusion period of a previous clinical trial, * Having received, during the last 12 months, indemnities for clinical trial higher or equal to 4500 Euros, * Under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision, * Presenting a psychological or linguistic incapability to sign the informed consent, * Impossible to contact in case of emergency, After V1 biological analysis the subjects will be considered as non eligible to the study on the following criteria: * Fasting blood triglycerides \> 4 g/L, * Fasting glycaemia \> 1.26 g/L * Blood AST, ALT or GGT \> 3xULN (Upper Limit of Normal), * Blood urea \> 12.11 mmol/L (value corresponding to 1.5xULN) or creatinine \> 125 μmol/L, * Blood hsCRP \> 10 mg/L, * Complete blood count with clinically significant abnormality according to the investigator. Within 3 months following to the exit of the study for failure to comply to one or more of the exclusion criteria listed above, a re-screening could be performed.