Safety and Efficacy of Resticutis Compared to Platelet-Poor Plasma for Treating Diabetic Foot Ulcers

Inclusion Criteria: * People with Type II Diabetes mellitus between the ages of 18 and 70 with an ulcer with at least 4 weeks duration. * Hb1c of less than 13 %. * Index foot ulcer located on the plantar, medial, or lateral aspect of the foot (including all toe surfaces), and wound area (length\*width) measurement between 0.5 cm\^2 and 20 cm\^2, inclusive. * Wounds located under a Charcot deformity has to be free of acute changes and went through appropriate structural consolidation. * Wagner Grade II or III ulcer. * The protocol requires that post-debridement, the ulcer would be free of necrotic debris, foreign bodies, or sinus tracts. * Non invasive vascular testing Ankle Brachial Index (ABI). * Physical examination (Including a Semmes-Weinstein monofilament test for neuropathy). * Blood tests to be obtained (CBC, Hb1c) * Approved, informed, signed consent to be obtained from each patient. Exclusion Criteria: * Patient currently enrolled in another investigative device or drug trial or previously enrolled (within the last 30 days) in an investigative research of a device or a pharmaceutical agent. * Ulcer area decreased \> 50% during the seven-day screening period. * Ulcer is due to a non-diabetic etiology. * Evidence of gangrene in ulcer or on any part of the foot. * Patient is currently receiving or has received radiation or chemotherapy within the last 3 months of randomization. * Patient has received growth factor therapy within 7 days of randomization. * Screening platelets count \< 100\* 10\^9/L. * Patient is undergoing renal dialysis, or has a known immune insufficiency, known abnormal platelets activation disorder (i.e. Grey Platelet Syndrome, Liver Disease, Active Cancer), eating/nutritional, hematologic, collagen vascular disease, rheumatic disease, or bleeding disorder. * History of peripheral vascular repair within 30 days of randomization. * Patient is known to have a physiological, developmental, physical, emotional, or social disorder, or any other situation that may interfere with their compliance with the study requirements and/or the healing of the ulcer. * History of alcohol or drug abuse within the last year prior to randomization. * Patient has inadequate venous access for blood withdraw.