The Epidemiology of Recurrent Spontaneous Abortion Associated With Thrombophilla

Shanghai First Maternity and Infant Hospital45,000 enrolled

Overview

RSA is a multifactorial disorder resulting from genetic factors, anatomic factors, autoimmune disorders, endocrine dysfunction, thrombophilia, life style factors, and maternal infections. However, the underlying causes remain undetermined in up to 50% of cases. In this clinical cohort study, we intended to get an epidemiological evidence for patients with recurrent spontaneous abortion associated with thrombophilla.

Study Type

OBSERVATIONAL

Enrollment

45,000

Conditions

Recurrent Pregnancy Loss

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Woman who had 2 miscarriages before 12(th) week of gestation.Signed consent form. Exclusion Criteria: 1. having experienced severe allergies, trauma history and/or operation history within 3 months; 2. with a history of mental illness and/or family history of mental illness 3. limb disabled 4. taking medicine within one month 5. suffering major events or having mood swings 6. with a history of recurrent pregnancy loss 7. having internal and surgical disease(after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine) 8. chromosome aberrations in anyone of the couple.

Locations (1)

Shanghai first Maternity and Infant health hospital, Tong Ji University

Shanghai, China

RECRUITING

Outcomes

Primary Outcomes

D-Dimer

Time frame: through study completion, an average of 3 year

Secondary Outcomes

BMI in kg/m^2

Time frame: through study completion, an average of 3 year

platelet aggregation time

Time frame: through study completion, an average of 3 year

anticardiolipin antibody

Time frame: through study completion, an average of 3 year

Data from ClinicalTrials.gov

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